Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Department of Pathology, Medical University of Pécs, Pécs, Hungary
Case Report
Resolution of Angina Pectoris in Five Patients with Myeloproliferative Neoplasms Treated with Pegylated Interferon Resistant Anginal: MPN Patient Treated with PEG-IFN
Author(s): Miklos Egyed*, Eszter Kovacs, Eva Karadi, Jozsef Herczeg, Béla Kajtár, Lasse Kjaer, Vibe Skov and Hans Carl Hasselbalch
The Philadelphia-negative chronic Myeloproliferative Neoplasms (MPNs) are characterised by the prevalence of somatic mutation JAK2V617F and associated with a high Cardiovascular Disease (CVD) burden, including ischemic heart disease with angina pectoris and heart failure, peripheral arterial insufficiency and risk the increase of such vascular malformations as aneurisms. Firing of the mutant Janus Kinase/Signal Transducers And Activators Of Transcription (JAK-STAT) signal transduction pathway results in blood cell count increase and induces the differentiation and maturation process of platelets and neutrophils. All these concomitant processes enhance the establishment of chronic inflammatory and thrombogenic state with a 12-times higher risk of coronary disease as a consequence. Long-term administration of Interferon-Alpha2 (rIFN) is proven to reduce the JAK2V6.. View More»
DOI:
10.35248/2329-6917.23.11.347