Immunome Research
Open Access
ISSN: 1745-7580
ISSN: 1745-7580
Department of Radiotherapy, Shandong Cancer Hospital, Jinan, China
Research Article
Low-Dose Radiation Improves the Tumor Immune Microenvironment through IFN Production: An In Vivo Study Using Murine Lung Cancer Model
Author(s): Jigang Dong*, Xindi Li, Shasha, Qi Ying and Baosheng Li
Background: Exposure to radiation prompts apoptosis within cancer cells, initiating ‘consume me’ signals
including phosphatidylserine and calreticulin. This activation of dendritic cells paves the way for immune
responses mediated by T and NKT cells, as well as the engulfment of cells by macrophages.
Objectives: In our study, we focused on the effects of low-dose radiation on Interferon (IFN) production,
thereby enhancing immunogenic cell death in tumor cells.
Methods: In a study utilizing a murine lung cancer model, Lewis Lung Carcinoma (LLC) cells were administered
to C57BL/6 mice. Following tumor development, these mice were segregated into cohorts. One cohort received
a regimen of low-dose radiation therapy, while another was treated with CTLA-4 antibody injections.
Res.. View More»