Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Biotechnology, St. Joseph’s College of Engineering, Chennai, Tamil Nadu, India
Research
In Silico Predictive Homology Modeling of PKHD-1 Protein: A Comparative Study among Three Different Species
Author(s): Arunannamalai SB*
Background: The PKHD-1 (Polycystic Kidney and Hepatic Disease-1) gene encodes a crucial protein vital for
renal and hepatic functions. Mutations in PKHD-1 result in Autosomal Recessive Polycystic Kidney Disease
(ARPKD), a severe disorder in early infancy. Despite its significance, the structural information on PKHD-1
remains limited, with few low-resolution structures accessible. Homology Modeling was employed to generate
structural models of PKHD-1 proteins from three species: Homo sapiens (Human), Mus musculus (Mouse) and Canis lupus familiaris (Dog). Various bioinformatics tools were utilized for analysis and validation.
Results: Structural models of PKHD-1 proteins from different species were generated using Homology Modeling
and advanced bioinformatics tools, including SWISS-Model, ProtParam, GOR4.. View More»
DOI:
10.35248/0974-276X.24.17.659