Journal of Antivirals & Antiretrovirals
Open Access

Laboratory of Microbiology and Virology, Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy

Publications

• Research Article   
  In Vitro Search for Antiviral Activity against Human Cytomegalovirus from Medicinal Mushrooms Pleurotus sp. and Lentinus sp.
  Author(s): Debsopan Roy, Sabbir Ansari, Aroni Chatterjee, Anna Luganini, Swapan Kumar Ghosh* and Nilanjan Chakraborty*
  
  Human Cytomegalovirus is a ubiquitous opportunist pathogen capable of infecting newborns, immune compromised and immunosuppressed patients. Till date only a limited number of clinically approved drugs are available for treatment. All these drugs prove to be very effective against active HCMV infection but with their respective share of drawbacks. Anti-viral agents derived from natural compounds are the need of the hour. They have potent anti-viral property but lack the cytotoxic effect associated with their synthetic counterparts. In this regard the medicinal mushrooms have proven to be quite an interesting candidate of choice. We collected and isolated extracts from four different edible mushroom species and used them on in vitro cultured MRC5 and 1B4 cell lines. Cytotoxicity and anti-viral response for each mushroom was tested in a dose dependent and time dependent fashion... View More»
  DOI: 10.35248/1948-5964.20.12.201

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