Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Amar Nijagal

Department of Pediatric Surgery, University of California, San Francisco, CA 94143-0570, USA

  • Review Article   
    The Relative Abundance of Monocyte Subsets Determines Susceptibility to Perinatal Hepatic Inflammation
    Author(s): Sarah Mohamedaly, Anas Alkhani and Amar Nijagal*

    The devastating consequences of perinatal liver inflammation contribute to a pressing need to develop therapeutics for the diseases that underly this condition. Biliary atresia (BA) is a perinatal inflammatory disease of the liver that results in obliterative cholangiopathy and rapidly progresses to liver failure, requiring transplantation. The ability to develop targeted therapies requires an understanding of the immune mechanisms that mitigate perinatal liver inflammation. This article reviews our recent findings demonstrating that in a murine model of perinatal hepatic inflammation, Ly6cLo non-classical monocytes express a pro-reparative transcriptomic profile and that the relative abundance of Ly6cLo monocytes promotes resolution of perinatal liver inflammation, rendering neonatal pups resistant to disease. We also examine the lineage rel.. Read More»
    DOI: 10.35248/2155-9899.20.11.602

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