Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

Amany M Nagdy

Department of Zoology, Beni-Suef University, Beni Suef, Egypt

  • Research Article   
    Synthesis, Characterization, Biological Activities and Molecular Docking of New Benzenesulfonamide Drugs
    Author(s): Hussein S Mohamed*, Zeinab S Hamza, Amany M Nagdy, Sayed A Ahmed and Osama M Ahmed

    There studies centering the potential usage of benzensulfonamide derivatives as anticancer agents are still limited. So, in this study, a series of new sulfonamide drugs were synthesized by the reaction of aldehydes thiosemi carbazones derivatives with benzene sulphonyl chloride to form benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide derivatives. Spectral techniques like Fourier Transformer Infrared Analysis (FTIR), Proton Nuclear Magnetic Resonance (1HNMR) and Mass spectroscopy were used to characterize the newly synthesized compounds. The two derivatives, 2-benzylidene-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4a) and 2-(4-chloro benzylidene)-N-(phenylsulfonyl) hydrazine-1-carbothioamide (4d) exhibited the most potent anticancer effects against MCF-7 breast carcinoma cell lines. Meanwhile, these two derivatives showed the lowest antioxidant activities. To study the.. View More»
    DOI: DOI: 10.35248/2161-0495.22.12.507

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