Journal of Cell Signaling
Open Access

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Publications

• Research Article   
  Cell Therapy in Transplantation
  Author(s): Aliakbar Amirzargar*, Amir Hossein Mansourabadi and Sara Bahramkiya
  
  Organ transplantation is an established and practical definitive treatment option for patients with end-stage organ dysfunction. Unlike improvements in short-term graft survival, long-term graft survival is the main challenge due to the increased morbidity and mortality associated with the toxicity of immunosuppressive regimens and chronic rejection. Since a novel therapeutic strategy to fulfill allograft tolerance seems urgent, the attention of the transplant community is focusing on the development of the new safe approach to prolong graft survival. Various researches have focused on immune regulation in the context of organ transplantation with mesenchymal stem cells and regulatory T cells (Tregs) identified as cells that have the potential to suppress or optimize the immune responses in different situations. In this review article, we will provide an overview.. View More»
  

  Abstract PDF