Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609

Akintayo C.O

Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ekiti State, Nigeria

  • Research Article   
    Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats
    Author(s): Akintayo C.O, Olukiran O.S*, Ayodele M.J and Karga S.V

    Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and prevalence of use continues to grow. Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats. Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5 rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA. Results: The serum concentrations of AST and ALT were significantly higher in groups 3, 4 and 5 when compared with groups 1 and 2. Groups 1 and 2 had LDL and HDL that were significantly lower than that of groups 3 and 4. Rats in group .. View More»
    DOI: 10.35248/2157-7609.23.14.271

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