Department of Biomedical Dental Sciences, Imam Abdulrahman bin Faisal University, Kingdom of Saudi Arabia
Does Rheumatoid Arthritis Affects the Nitrergic Density and Somatic Area of the nNOS-Immunoreactive (IR) Myenteric Neurons, as well as the Morphometric Areas of CGRP and VIP-IR Varicosities of the Ileum of Arthritic Rats?
Author(s): Ahmed S Ashour and Virginia K*
Few studies regarding arthritic diseases have been performed to verify the presence of the neurodegeneration. Given the increased oxidative stress and extra-articular effects of the rheumatoid arthritis, the gastrointestinal studies should be further investigated aiming a better understanding of the systemic effects the disease on enteric nervous system. To determine whether the rheumatoid arthritis affects the nitrergic density and somatic area of the nNOSimmunoreactive (IR) myenteric neurons, as well as the morphometric areas of CGRP and VIP-IR varicosities of the ileum of arthritic rats. Twenty 58-day-old male Holtzmann rats were distributed in two groups: control and arthritic. The arthritic group received a single injection of the Freund’s Complete Adjuvant in order to induce arthritis model. The whole-mount preparations of ileum were processed for immunohistochemistry to V.. Read More»