Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Xiao-hui Li
China
Research Article
Noninvasive Versus Invasive Mechanical Ventilation to Treat Patients with Hypercapnic Acute Respiratory Failure Secondary to COPD
Author(s): Jin-xiang Wang, Lin Ding, Cong-feng Li and Xiao-hui LiJin-xiang Wang, Lin Ding, Cong-feng Li and Xiao-hui Li
Objective: Noninvasive ventilation (NIV) had been successfully used in patients with severe hypercapnic acute respiratory failure (HARF). Being lack of a large number of randomized control trials to support NIV in chronic obstructive pulmonary disease (COPD) patients with severe HARF, the effect of NIV for patients with life-threatening HARF should be further confirmed. In order to confirm the effect of NIV on selected patients with HARF due to COPD, we conducted a comparative prospective observational study of NIV vs. IMV (invasive mechanical ventilation) + NIV in COPD patients with HARF.
Methods: A total of 420 patients with acute respiratory failure secondary to COPD were prospective screened; 52 cases with PaCO2 ≥ 90 mmHg or PaCO2 <90 mmHg but ≥ 80 mmHg with pH value ≤ 7.20 were enrolled. Twentyone cases received sequential IMV .. View More»
DOI:
10.4172/2165-8048.1000297