Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-20-4587-4809
ISSN: 2157-7048
+44-20-4587-4809
Siti Efliza Ashari
Faculty of Science,
43400 UPM Serdang, Selangor
Malaysia
Research Article
Evaluation of Direct Esterification of Fatty Acid Derivative of Kojic Acid in
Co-solvent System: A Statistical Approach
Author(s): Fatin Amirah Ahmad Norddin, Sharifah Nurfadhlin Afifah Syed Azhar and Siti Efliza AshariFatin Amirah Ahmad Norddin, Sharifah Nurfadhlin Afifah Syed Azhar and Siti Efliza Ashari
The present work deals with direct esterification method to synthesize Kojic acid using immobilized lipase as a biocatalyst in acetonitrile with the addition of dimethylsulfoxide (DMSO) as a solubilizing agent Co-solvent respectively. To increase the esterification yield of KMO, modifications of the process were evaluated, including the use of a cosolvent and the use of Novozyme 435 (Candida antarctica) as a catalyst. The KMO synthesis has been developed and optimized by using Response Surface Methodology (RSM) with Central Composite Rotatable Design (CCRD). The optimized condition of enzyme was 3.35 wt% and 1:3.64 molar ratio of kojic acid and oleic acid at 82.39°C for 255.24 min of reaction. With these condition, the maximum percentage yield was 42.73% with R2 value of 0.866914 and indicated that 86.69% of the variability in the response could be explained by the model.. View More»
DOI:
10.4172/2157-7048.1000331