Journal of Applied Pharmacy
Open Access
ISSN: 1920-4159
ISSN: 1920-4159
Sathish Kumar Chinnasamy
India
Research Article
Nanopeptides: Non - Covalent Interactions in Chemistry and Biological
Functions
Author(s): Chinnasamy Selvakkumar, Karthikeyan Muthusamy and Sathish Kumar ChinnasamyChinnasamy Selvakkumar, Karthikeyan Muthusamy and Sathish Kumar Chinnasamy
The interactions involving the side chains of weakly polar aromatic amino acid residues, e.g., Phenylalanine (Phe), Tyrosine (Tyr) and Tryptophan (Trp) generally reside at the interior of proteins and help in the stabilization of globular protein structures. The aromatic electron cloud of the aromatic rings of these amino acids are delocalized on both sides of the planer rings, so that there is a small partial negative charge on the face and a small partial positive charge on the hydrogen atoms of the edge, which leads to the possibility of electrostatic interactions. These interaction play a vital role nanofiber based vaccine adjuvants, and cocaine vaccine development and increasing interest and structure-based drug development. Apart from electrostatic forces, aromatic interactions also consist of van der Waals and hydrophobic forces. These weakly polar interactions are enthalpicall.. View More»
DOI:
10.4172/1920-4159.1000218