Journal of Chemical Engineering & Process Technology
Open Access

Safaa M Yousif

Publications

• Research Article
  Microencapsulation of Ibuprofen into Polyvinylpyrrolidone Using Supercritical Fluid Technology
  Author(s): Safaa M Yousif, Ali H Al-Marzouqi and Mahmoud A MohsinSafaa M Yousif, Ali H Al-Marzouqi and Mahmoud A Mohsin
  
  Osteoarthritis is a disease that attacks human bones especially in older people and usually non-steroidal antiinflammatory drugs are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low aqueous solubility, dissolution and bioavailability. In order to maximize their therapeutic effects, these properties should be develped and enhanced. The purpose of this study was to reduce the particle size of ibuprofen by forming microparticles and thus enhance its dissolution rate. Ibuprofen was encapsulated into a polymer (polyvinylpyrrolidone) using supercritical fluid technology (supercritical CO2) to form drug-polymer microparticles. Dissolution rate and surface characteristics of the prepared drug-polymer microparticles were measured using various characterization techniques such as fourier transform infrared spectroscopy (FTIR), ultraviolet spect.. View More»
  DOI: 10.4172/2157-7048.1000306

  Abstract PDF

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