Lupus: Open Access
Open Access

Renaudineau Y

Publications

• Editorial
  Anti-Sm and Anti-U1-RNP Antibodies: An Update
  Author(s): Lemerle J, Renaudineau YLemerle J, Renaudineau Y
  
  From their discovery anti-Sm autoantibodies (Ab) have been associated with systemic lupus erythematosus (SLE), while anti-U1-RNP Ab detected alone are predominant in patients with mixed connective disease (MCTD). However, the identification of anti-Sm/U1-RNP Ab in a patient may be challenging, and usually requiring a two-step process including a screening step performed by indirect immunofluorescence (IIF) on HEp-2 cells showing a coarse speckled nuclear staining at an elevated level, followed by a confirmatory assay using specific antigens. The recent development of novel assays and the characterization of the target epitopes have been beneficial to improve the sensitivity for anti-Sm/U1-RNP Ab detection, but, in some cases, the necessity to use a different assay remains mandatory. Another recent and unexpected observation is related to the suspected role played by environmental and .. View More»
  DOI: 10.35248/2684-1630.16.1.e104

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