Lupus: Open Access
Open Access
ISSN: 2684-1630
ISSN: 2684-1630
Pradhan VD
National Institute of Immunohaematology (ICMR),
Mumbai
India
Research Article
Pentraxin-3 and its Association with C1q-CIC, hsCRP and Pro-Inflammatory Cytokines (TNF-Α and IL-1β) among SLE Patients from India
Author(s): Khadilkar PV, Umare VD, Rajadhyaksha A, Chougule DA, Vaidya SP, Deshpande SD, Nadkarni AH and Pradhan VDKhadilkar PV, Umare VD, Rajadhyaksha A, Chougule DA, Vaidya SP, Deshpande SD, Nadkarni AH and Pradhan VD
Introduction: Systemic Lupus Erythematosus (SLE) is a prototype autoimmune disease with alternating periods of flares and remission. Disease pathogenesis involves vast inflammatory responses, characterized by impaired cell signaling and T-cell dysfunction with interplay of cytokines and a wide network of protein cascades. Aim of this study is to understand the correlation between PTX-3 and pro-inflammatory cytokines (TNF-α and IL-1β) and their role in disease pathogenesis of SLE.
Materials and Methods: Sixty-three SLE patients classified as per ACR 1997 criteria were included, of which 36 had renal involvement (LN). Autoantibodies were detected by IFA and ANA BLOT techniques. Serum Complement levels and hsCRP (by nephelometer), Pentraxin-3 and C1q-CIC (by ELISA), TNF-α and IL-1β levels (by Multiplex immunoassay) were asses.. View More»
DOI:
10.35248/2684-1630.17.2.122