Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
ISSN: 2157-7048
Phung Kim Le
Faculty of Chemical Engineering, Ho Chi Minh City University of Technology,
Vietnam
Research Article
The Effect of Rapid Expansion of Supercritical Solution (RESS) Parameter on
Sub-Micron Ibuprofen Particle Forming
Author(s): Phung Kim Le and Kien Anh LePhung Kim Le and Kien Anh Le
Rapid expansion of supercritical solution (RESS) is the most common method of pharmaceutical particle forming approaches using supercritical fluids. The RESS method is a technology which produces a small solid product with a very narrow particle size distribution, organic solvent-free particles. This process is also simple and easy to control the operating parameters in comparison with other methods based on supercritical techniques. In this study, Ibuprofen, anon steroidal anti-inflammatory drugs (NSAID), has been micronized by RESS; the size and morphology effects of three different RESS parameters including extraction temperatures, extraction pressures and expansion nozzle temperatures have been investigated and optimized by response surface method. The particle size distribution has been measured by Light diffraction scattering (LDS) method. SEM has been used to analyze the surfac.. View More»
DOI:
10.4172/2157-7048.1000220