Journal of Applied Pharmacy
Open Access

Partha Pratim Bose

Publications

• Short Communication
  Targeted Delivery of Paromomycin to Leishmania Infected Macrophage by Hemoglobin Tagged Nanocarrier
  Author(s): Partha Pratim Bose and Prakash KumarPartha Pratim Bose and Prakash Kumar
  
  Purpose: After the extensive resistance of the first line of antimonial drugs, paromomycin, the broad-spectrum antibiotic has become the treatment of choice against visceral leishmaniasis, the fatal tropical disease. However, unfavorable distribution in the intracellular compartment of macrophage, prolonged parenteral administration procedure and toxicity limit the use of paromomycin. Lack of availability of specific delivery system also makes this drug unsafe. Thus, a specific and nontoxic formulation of paromomycin is an urgent need. Materials and method: A chitosan-chondroitin sulfate based nano-formulation has been developed and hemoglobin has been tagged on the surface of the delivery system for the specific carriage of paromomycin to the leishmania infected macrophage taking the advantage of Leishmania being highly auxotrophic for heme.. View More»
  DOI: 10.4172/1920-4159.1000212

  Abstract PDF

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