Journal of Women's Health Care

Journal of Women's Health Care
Open Access

ISSN: 2167-0420


Paola Rossi

Paola Rossi

Via Ferrata 9, Pavia-27100

  • Review Article
    Role of 17?-Estradiol in Learning and Memory
    Author(s): Paola Rossi and Valentina CesaroniPaola Rossi and Valentina Cesaroni

    Ovarian hormones regulate a wide variety of non-reproductive functions in the central nervous system by interacting with several molecular and cellular processes. Estrogens are steroid hormones that are synthesized in the gonads [peripherally-synthesized or “neuroactive steroids”] as well as in various tissues throughout the body, including the brain [brain-synthetized or “neurosteroids”]. 17β-Estradiol [E2] is the most potent and predominant form of estrogen. E2 has a number of effects on cognition and brain function. The effects on memory depend on hormone levels and on binding to different estrogen receptors within neural circuits. The purpose of this review is to highlight the complex relationship between E2 and cognitive functioning, analyzing the difference of effects described by observational studies compared to randomized controlled large-s.. View More»
    DOI: 10.4172/2167-0420.1000282

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