ISSN: 2168-9784
+44 1300 500008
Numbara Deebii
Rivers State
Nigeria
Research Article
Immunopotentiation in the Presence of Tenofovir-induced Phosphaturia in HIV-infected Patients on Tenofovir
Author(s): Numbara D
Numbara D
Tenofovir disoproxil fumarate (TDF) remains the most widely use and prescribed first line antiretroviral therapy in the treatment of patients infected HIV-infection but unfortunately it is possibly nephrotoxic especially on the kidney tubules. In this longitudinal study we evaluated the influence of TDF on the renal tubules, measuring urinary phosphate and protein. 57 patients infected with HIV were recruited and grouped as follows: TDF group (21 patients), Non-TDF group (21 patients) and treatment naïve group (15 patients). Indicators of renal tubular injuriousness together with other common biomarkers of renal injury were evaluated. Phosphaturia was defined as urinary phosphate 20.0 mg/dl and the prevalence of phosphaturia after 12 weeks of follow-up were as follows: TDF group (8), Non-TDF group (1) and treatment naïve group (3). Proteinuria was defined as positive protein.. View More»
DOI:
10.4172/2168-9784.1000238