Journal of Applied Pharmacy
Open Access

Neha Singh

Publications

• Research Article
  A Comparative Study of Solubility Enhancement of Aceclofenac by Solid Dispersion Technique Using Several Polymers
  Author(s): Manoj Kumar Sarangi and Neha SinghManoj Kumar Sarangi and Neha Singh
  
  The attempt has been made to compare the aqueous solubility and dissolution characteristics of Aceclofenac (ACE) enhanced by solid dispersion technique using several water soluble carriers PEG 6000, β-Cyclodextrin (β –CD) and Sodium Carboxy methyl cellulose (Na-CMC). Solid dispersions of ACE were prepared with solvent evaporation method. Solid dispersions with carriers were prepared in drug: carrier (1:1, 1:2, 1:3 and 1:4) ratios. The prepared dispersions were evaluated by solubility, in vitro dissolution studies and X-Ray diffraction studies (XRD). The results from XRD analysis showed that ACE might exist in an amorphous state in the solid dispersion. Considerably improved dissolution profile was obtained by PEG ratios (1:2), whereas there was no significant improvement in dissolution of ACE along with β-CD at higher carrier ratios. Na- CMC showed least .. View More»
  

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