Journal of Chemical Engineering & Process Technology

Journal of Chemical Engineering & Process Technology
Open Access

ISSN: 2157-7048

+44-77-2385-9429

Nayera AM Abd El-Wahed

Publications
  • Research Article
    Synthesis of Novel Series of Phthalazine Derivatives with Antibacterial and Antifungal Evaluation
    Author(s): Maher A El-Hashash, Dalal B Guirguis, Nayera AM Abd El-Wahed and Mohamed A KadhimMaher A El-Hashash, Dalal B Guirguis, Nayera AM Abd El-Wahed and Mohamed A Kadhim

    The oxirane derivative (2) was allowed to react with hydrazine hydrate, 4-aminobenzoic acid and o-phenylene diamine to give β-hydrazine alcohol derivative (3) and β-amino derivatives (4) and (5). The hydrazide (8) reacted with glucose, phthalic anhydride and aromatic aldehydes to give the phthalazine derivatives (9), (15) and (16a-c). A new heterocyclic molecules were synthesized using ethyl acetoacetate, acetyl acetone and benzoyl chloride with the hydrazide (8) to give the pyrazole derivatives (12), (14) and the oxadiazole derivative (18). The new compounds were synthesized with the objective of studying their antifungal and antimicrobial activity. Some of them gave positive results. The newly synthesized compounds were characterized on the basis of their spectral (1H-NMR, Mass spectrum, IR and Elementary analysis)... View More»
    DOI: 10.4172/2157-7048.1000195

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