Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Mojtaba Ruhani
West Indies
Research Article
Detection of BTNL2 Gene Mutation (rs2076530 Allele) in Iranian Sarcoidosis Patients: A clinical and Genetic Study
Author(s): Reza Vazifehmand, Tina Saber, Hamid Reza Khorram Khorshid, Dhuha Saeed Ali, Foroozandeh monem homaie and Sassan SaberReza Vazifehmand, Tina Saber, Hamid Reza Khorram Khorshid, Dhuha Saeed Ali, Foroozandeh monem homaie and Sassan Saber
Background/Aims: Sarcoidosis is a multiorgan granulomatous inflammatory disease of an unknown cause, probably due to inappropriate T-cell response. Mutation in BTNL2 gene (Butirophylin-like2) which is one of the most important genes in MHC II (complex tissue incompatibility) group is related to sarcoidosis. Our purpose was to evaluate BTNL2 rs2076530 G/A allele as a putative genetic risk for sarcoidosis in an Iranian population.
Methods: DNA from patients and controls was obtained from peripheral blood using standard methods. 490-bp amplicon of each samples were genotyped for the BTNL2 G → A transition of rs2076530 using an ABI 3130 automated sequencer-Big-Dye Terminator Version 3.1 Cycle.
Results: A total of 50 patients with sarcoidosis were registered in our study of which 33 were females (66%) and 17 were m.. View More»
DOI:
10.4172/2165-8048.1000239