International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
ISSN: 2329-9096
Michael Legge
New Zealand
Research Article
Case-Controlled, Cross-Sectional Evidence that Spinal Cord Injury Associated with Sympathetic Decentralisation may Alter Osteocalcin Signalling
Author(s): Lynnette M Jones, Michael Legge and Lee StonerLynnette M Jones, Michael Legge and Lee Stoner
Objective: Osteocalcin has been shown to exert an endocrine influence on bone and energy metabolism in both animals and humans; recent evidence indicating a regulatory role for osteocalcin in glucose homeostasis and energy metabolism and as a marker for bone metabolism. The aim of this study was to investigate the interaction between osteocalcin, body composition, and blood biomarkers in men with spinal cord injury (SCI) compared with able-bodied male controls. Materials and Methods: Twenty men with SCI were matched for age, height, and weight with 20 able-bodied controls. Body composition, bone density and blood levels of adiponectin, leptin, insulin, glucose, insulin-like growth factor-1 (IGF-1) were undertaken. Total body and regional fat mass (FM), fat free mass (FFM), total body bone mineral density (BMD) and circulating levels of blood biomarkers were compared b.. View More»
DOI:
10.4172/2329-9096.1000224