Journal of Pharmacological Reports
Open Access
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Masanori Takaokac
Japan
Research Article
α-Lipoic Acid Exerts a Primary Prevention for the Neointimal Hyperplasia in Balloon-Injured Rat Carotid Arteries.
Author(s): Daisuke Kurumazukaa, Hisashi Shirakawaa, Sayaka Kimuraa, Tatsuhiko Morib, Yasuo Matsumuraa and Masanori TakaokacDaisuke Kurumazukaa, Hisashi Shirakawaa, Sayaka Kimuraa, Tatsuhiko Morib, Yasuo Matsumuraa and Masanori Takaokac
Background: It has been reported that α-lipoic acid is an anti-oxidative and anti-inflammatory agent, and exhibits beneficial effects in experimental disease models such as hypertension and acute kidney injury. In the present study, we examined effects of α-lipoic acid on neointimal hyperplasia in balloon-injured carotid arteries. Methods: Male rats underwent balloon injury of the right carotid artery with a 2F Fogarty balloon catheter. α- Lipoic acid was administrated to balloon-injured rats in the following treatment schedules; (1) days -3 to 14, (2) days -3 to 3, (3) days 7 to 14 and (4) vehicle. We evaluated the neointimal formation, NADPH oxidase-dependent superoxide production, nitrotyrosine expression and p50 subunit of nuclear factor kappa B (NF-κB p50) expression in balloon-injured and uninjured carotid arteries. Results: In vehicle-treated rats, a sig.. View More»