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Journal of Medical & Surgical Pathology

Journal of Medical & Surgical Pathology
Open Access

ISSN: 2472-4971

Mark I.M. Noble

Mark I.M. Noble

Polwarth Building, Foresterhill, berdeen AB25 2ZH
United Kingdom

Publications
  • Commentary
    Commentary: On the Pathophysiology of Coronary Heart Disease
    Author(s): Mark I.M. NobleMark I.M. Noble

    This article highlights some important aspects of the pathophysiology of coronary artery disease, namely: • The distribution of lesions within the arterial tree at sites of low wall shear stress. • The potential role of low flow-mediated arterial dilatation at sites of low wall stress. • Low flow-mediated dilatation leads to low nitric oxide production by the arterial endothelium and consequent reduced protection against lesion formation. • Flow-mediated dilatation is reduced by high lumenal glucose concentration. • The role of the glycocalyx dysfunction in mediating flow-mediated dilatation and consequent reduced NO production by the arterial endothelium and cell adhesion. • Stenoses cause convective acceleration of blood velocity and a consequent increase in platelet shear stress. • Increased platele.. Read More»
    DOI: 10.4172/2472-4971.1000147

    Abstract PDF

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