Journal of Medical & Surgical Pathology
Open Access

Mark I.M. Noble

Publications

• Commentary
  Commentary: On the Pathophysiology of Coronary Heart Disease
  Author(s): Mark I.M. NobleMark I.M. Noble
  
  This article highlights some important aspects of the pathophysiology of coronary artery disease, namely: • The distribution of lesions within the arterial tree at sites of low wall shear stress. • The potential role of low flow-mediated arterial dilatation at sites of low wall stress. • Low flow-mediated dilatation leads to low nitric oxide production by the arterial endothelium and consequent reduced protection against lesion formation. • Flow-mediated dilatation is reduced by high lumenal glucose concentration. • The role of the glycocalyx dysfunction in mediating flow-mediated dilatation and consequent reduced NO production by the arterial endothelium and cell adhesion. • Stenoses cause convective acceleration of blood velocity and a consequent increase in platelet shear stress. • Increased platele.. View More»
  DOI: 10.4172/2472-4971.1000147

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