Marius C. Van den Heuvel
Re-Occurring Proteinuria in a SLE Patient: Always Lupus Nephritis?
Author(s): Henk A. Martens, Marc Bijl, Marius C. Van den Heuvel and Cees G.M. KallenbergHenk A. Martens, Marc Bijl, Marius C. Van den Heuvel and Cees G.M. Kallenberg
Introduction: Renal disease, designated as lupus nephritis (LN), is one of the severe manifestations of Systemic Lupus Erythematosus (SLE). The proliferative forms require aggressive treatment with corticosteroids and cytotoxic drugs. In a substantial number of patients, renal disease relapses after treatment. Case report: In this case report, we present a 27-year old woman, who had been treated for a membranoproliferative LN in the past. Seventeen years later she presented with chest pain and nephrotic-range proteinuria and severe hypoalbuminemia. The diagnosis of pulmonary embolism was made. Renal biopsy revealed only minimal abnormalities, confined to the mesangium. There was no glomerulonephritis. Based on this finding and the nephrotic-range proteinuria, the diagnosis of minimal-change disease was made. The patient was treated with prednis.. Read More»