Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Marina I. Arleevskaya
State Medical Academy,
11, Moushtary St, Kazan, Tatarstan
Serbia
Editorial
How Herpesviridae Combined with other Viral Infections can Trigger and Drive Rheumatoid Arthritis
Author(s): Marina I. Arleevskaya, Olga A. Kravtsova, Anatoly P. Tsibulkin, Julie Lemerle and Yves RenaudineauMarina I. Arleevskaya, Olga A. Kravtsova, Anatoly P. Tsibulkin, Julie Lemerle and Yves Renaudineau
Rheumatoid arthritis (RA) development results from an inadequate immune response to environmental challenges in genetically predisposed patients. The list of viruses associated with RA is still growing, and includes the cytomegalovirus, the Epstein-Barr virus, and the herpes simplex viruses. Several hypotheses support their causative role. Firstly, RA development may result from a polyviral community or the cumulative effect of several microbial/viral factors thus explaining the absence of a single defined pathogen. Secondly, the process of RA development from preclinical to late-stage disease may result from cumulative episodes of viral infections caused by distinct pathogens. Thirdly, viral agents may trigger RA when associated with other factors such as tobacco, ethnic differences, psychological stress, inflammation, or chronic joint tissue micro-trauma. On the other hand, others c.. View More»
DOI:
10.35248/2684-1630.16.1.e102