Hair Therapy & Transplantation
Open Access
ISSN: 2167-0951
+44-20-4587-4809
ISSN: 2167-0951
+44-20-4587-4809
Marijana Vičić
University Hospital Center Rijeka,
Krešimirova 42, 51 000 Rijeka
Croatia
Research Article
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment
Author(s): Ines Brajac, Marijana Vičić, Darinka Periša and Marija KaštelanInes Brajac, Marijana Vičić, Darinka Periša and Marija Kaštelan
The Hair Follicle (HF) is a vital component of mammalian skin and represents a unique, highly regenerative system that undergoes phases of rapid growth, regression, and resting periods. The hair cycling is of profound clinical relevance since majority of the hair growth disorders occur as a result of cycle changes. The influence of many molecules governing the formation of HF has been investigated and many of important cycle mediators have been identified. Cellular and molecular events during cycling are controlled by a network of sequential activation of autocrine, paracrine and endocrine signaling pathways. This implies variations in the expression or activity of the Wnt family molecules, Fibroblast Growth Factor (FGF), Transforming Growth Factor β (TGF-β), Hedgehog pathway, β-Catenin pathway, noggin, transcription factor Stat3, Epidermal Growth Factor (EGF), Insulin .. View More»
DOI:
10.4172/2167-0951.1000115