Journal of Chemical Engineering & Process Technology
Open Access

Manobjyoti Bordoloi

Publications

• Research Article
  A Simple Efficient Process for the Synthesis of 16-Dehydropregnenolone Acetate(16-Dpa) - A Key Steroid Drug Intermediate from Diosgenin
  Author(s): Pritish Chowdhury, Juri Moni Borah, Manobjyoti Bordoloi, Pradip K. Goswami, Aradhana Goswami, Nabin C.Barua and Paruchuri G. RaoPritish Chowdhury, Juri Moni Borah, Manobjyoti Bordoloi, Pradip K. Goswami, Aradhana Goswami, Nabin C.Barua and Paruchuri G. Rao
  
  A three step efficient synthesis for the commercial production of 16-dehydropregnenolone acetate (16-DPA)-a potent steroid drug intermediate, from diosgenin, in an overall yield of 60%, has been developed, through generation of acetylonium ion (CH3C+=O) in optimum concentration from acetic anhydride using in the molar ratio of 1:3.5(diosgenin:Ac2O) in a pressure reactor in a medium of a hydrocarbon solvent at a temperature in the range of 200oC with the corresponding in-built pressure of 5-6kg/cm2 (Step 1) and an ultra sound irradiated (35 KHz) oxidation reaction (Step 2)... View More»
  DOI: 10.4172/2157-7048.1000117

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