Journal of Pharmacological Reports
Open Access
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+44-20-4587-4809
Manmeet Singh
India
Research Article
Comparative Disposition Kinetics and Bioavailability of Ofloxacin after Extravascular Administration in Buffalo (Bubalus bubalis) Calves
Author(s): Pratishtha Sharma, Ashok Gaur, Manmeet Singh and Satish K GargPratishtha Sharma, Ashok Gaur, Manmeet Singh and Satish K Garg
Comparative disposition kinetics of ofloxacin was studied in buffalo calves following its Intramuscular (IM) and Subcutaneous (SC) administration @ 5 mg/kg body weight. Plasma ofloxacin concentrations were determined by microbial assay method using E. coli as test organism. Ofloxacin could be determined in plasma within 2.5 min of drug administration and peak levels of 2.37 ± 0.06 and 2.20 ± 0.02 μg/ml were observed at 0.75 and 1.0 h after IM and SC administration, respectively. Blood levels of around 0.25 μg/ml were observed for up to 24 h and pharmacokinetics was best described by two-compartment open model following both the routes. Absorption and elimination half life values were found to be 0.14 ± 0.02 and 22.88 ± 81.97 h after IM administration while 0.18 ± 0.04 and 28.25 ± 2.04 h after SC administration. The AUC values after IM an.. View More»