Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-20-4587-4809
ISSN: 2157-7048
+44-20-4587-4809
Mahmoud A Mohsin
PO Box 27272, Sharjah
United Arab Emirates
Research Article
Microencapsulation of Ibuprofen into Polyvinylpyrrolidone Using
Supercritical Fluid Technology
Author(s): Safaa M Yousif, Ali H Al-Marzouqi and Mahmoud A MohsinSafaa M Yousif, Ali H Al-Marzouqi and Mahmoud A Mohsin
Osteoarthritis is a disease that attacks human bones especially in older people and usually non-steroidal antiinflammatory drugs are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low aqueous solubility, dissolution and bioavailability. In order to maximize their therapeutic effects, these properties should be develped and enhanced. The purpose of this study was to reduce the particle size of ibuprofen by forming microparticles and thus enhance its dissolution rate. Ibuprofen was encapsulated into a polymer (polyvinylpyrrolidone) using supercritical fluid technology (supercritical CO2) to form drug-polymer microparticles. Dissolution rate and surface characteristics of the prepared drug-polymer microparticles were measured using various characterization techniques such as fourier transform infrared spectroscopy (FTIR), ultraviolet spect.. View More»
DOI:
10.4172/2157-7048.1000306