Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-77-2385-9429
ISSN: 2157-7048
+44-77-2385-9429
Maher A El-Hashash
Egypt
Research Article
Synthesis of Novel Series of Phthalazine Derivatives with Antibacterial and Antifungal Evaluation
Author(s): Maher A El-Hashash, Dalal B Guirguis, Nayera AM Abd El-Wahed and Mohamed A KadhimMaher A El-Hashash, Dalal B Guirguis, Nayera AM Abd El-Wahed and Mohamed A Kadhim
The oxirane derivative (2) was allowed to react with hydrazine hydrate, 4-aminobenzoic acid and o-phenylene diamine to give β-hydrazine alcohol derivative (3) and β-amino derivatives (4) and (5). The hydrazide (8) reacted with glucose, phthalic anhydride and aromatic aldehydes to give the phthalazine derivatives (9), (15) and (16a-c). A new heterocyclic molecules were synthesized using ethyl acetoacetate, acetyl acetone and benzoyl chloride with the hydrazide (8) to give the pyrazole derivatives (12), (14) and the oxadiazole derivative (18). The new compounds were synthesized with the objective of studying their antifungal and antimicrobial activity. Some of them gave positive results. The newly synthesized compounds were characterized on the basis of their spectral (1H-NMR, Mass spectrum, IR and Elementary analysis)... View More»
DOI:
10.4172/2157-7048.1000195