Journal of Pharmacological Reports
Open Access
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+44-20-4587-4809
Kus K
Poland
Research Article
Comparison between Sexes during the Development of Atherosclerosis in
apoE & eNOS: Double Knockout Mice
Author(s): Wisniewska A, Kus K, Toton-Zuranska J, Jawien J, Olszanecki R and Korbut RWisniewska A, Kus K, Toton-Zuranska J, Jawien J, Olszanecki R and Korbut R
The aim of the study was to investigate differences between sexes in time – dependent development of atherosclerosis in apoE & eNOS – double knockout mice. At four time points, groups of female and male mice were sacrificed and the size of atherosclerosis was measured by “cross section”. At the age of 2 months, there was no difference between males and females. However, at the age of 4 months, the atherosclerosis was significantly bigger in females than in males (55,616 ± 4,622 μm2 vs. 37,181 ± 4,142 μm2; p<0.05). At the age of 6 months, the differences were even more pronounced (314,465 ± 19,351 μm2 vs. 108,277 ± 24,549 μm2; p<0.001). The same tendency was present at the age of 12 months (488,356 ± 49,823 μm2 vs. 201,646 ± 43,886 μm2; p<0.001). We describe for the first time the developme.. View More»