Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-20-4587-4809
ISSN: 2157-7048
+44-20-4587-4809
Kayghobad Shams
Isfahan University of Technology,
Isfahan 84156-83111
West Indies
Research Article
Nanoencapsulation of Insulin Using Blends of Biodegradable Polymers and
In Vitro Controlled Release of Insulin
Author(s): Vida Rahmani, Kayghobad Shams and Hamidreza RahmaniVida Rahmani, Kayghobad Shams and Hamidreza Rahmani
The purpose of this study was achieving an optimum formulation with low initial burst and steady-state release of insulin from the nanoparticles prepared with different blends of poly(lactide-co-glycolide) (PLGA), polylactic acid (PLA), poly(?-caprolactone) (PCL) and Eudragit� RS100 polymers. Insulin was encapsulated in different blends of these polymers using W/O/W double emulsion technique. Methylene chloride was used as the organic solvent and poly(vinyl alcohol) was used as the stabilizer in the external aqueous phase. The prepared nanoparticles revealed high encapsulation efficiencies (average 81.0%), showing that different compositions of the polymers did not have much effect on encapsulation efficiencies and loading capacities. AFM analyze showed a minimum particle size of 300 nm and maximum particle size of 900 nm. The in vitro release profiles indicated that the PLGA/PLA: 45%/55.. View More»
DOI:
10.4172/2157-7048.1000228