Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Jun Xue
Huashan Hospital,
12 middle Wulumuqi Road, Shanghai 200040
Indiana
Short Communication
The Influence of GSTA1 Polymorphism to the Response to Intravenous Cyclophosphamide Therapy in the Lupus Nephritis Patients
Author(s): Hong-Na Wang, Xiao-Ye Zhu, Ying Zhu, Miao Zhao, Yuan-Cheng Chen, Jun Xue, Chuan-Ming Hao, Yong Gu and Shan-Yan LinHong-Na Wang, Xiao-Ye Zhu, Ying Zhu, Miao Zhao, Yuan-Cheng Chen, Jun Xue, Chuan-Ming Hao, Yong Gu and Shan-Yan Lin
Variations of clinical response of cyclophosphamide (CTX) treatment in lupus nephritis (LN) could still be recognized. LN patients with a GSTA1mutation (CT heterozygous) had a risk of none-response (P=0.005). Pharmacokinetics data indicated that patients with a GSTA1 heterozygous variant had a lower exposure to 4-OHCTX compared to wild-type patients (P=0.023). And clinical efficacy was significantly related to higher exposure to 4- OH-CTX (P=0.038). In conclusion, LN patients with GSTA1 heterozygousgenotypes had poor CTX treatment response due to less exposure to activated 4-OH-CTX... View More»
DOI:
10.35248/2684-1630.16.1.115