Lupus: Open Access

Lupus: Open Access
Open Access

ISSN: 2684-1630

+44 1300 500008

Julie Lemerle

Julie Lemerle


  • Editorial
    Anti-DNA and Anti-Nucleosome Antibodies: An Update
    Author(s): Julie Lemerle, Wesley H Brooks and Yves RenaudineauJulie Lemerle, Wesley H Brooks and Yves Renaudineau

    Among the large spectrum of autoantibodies (Ab) detected in systemic lupus erythematosus (SLE), anti-dsDNA Ab have been used to diagnose and assess disease activity for more than 60 years. Anti-dsDNA Ab are often associated with anti-nucleosome Ab, and in clinical practice combining both is helpful for diagnosis, prognosis, and as biomarkers to monitor response to treatment, especially when using drugs that target B cells and Ab production. In general, the association of anti-dsDNA Ab plus anti-nucleosome Ab is linked with disease flares and can indicate lupus nephritis. Moreover and since anti-nucleosome Ab have higher sensitivity and specificity than anti-dsDNA Ab, the former is a useful marker in SLE patients negative for anti-dsDNA Ab and in the diagnosis of certain types of drug-induced lupus... View More»
    DOI: 10.35248/2684-1630.17.2.e105

    Abstract PDF

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