Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
+44 1300 500008
ISSN: 2165-8048
+44 1300 500008
Jie Liu
Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center,
Shanghai, 200065
China
Case Report
Case Report of an Unusual Stroke-like Creutzfeldt - Jakob disease with Medulla Oblongata Motor Nuclei Lesion
Author(s): Cheng-fang Huang, Xi Chen, Dan Jiang, Hua-li Wang, Hong-hua JIN, Wei Yang, Jun Peng, Jie Liu and Hong ZhangCheng-fang Huang, Xi Chen, Dan Jiang, Hua-li Wang, Hong-hua JIN, Wei Yang, Jun Peng, Jie Liu and Hong Zhang
Background: The reports of long-term imaging traces for sporadic Creutzfeldt–Jakob disease (sCJD) have been rare to date, although diffusion-weighted imaging (DWI) has high sensitivity and specificity in the diagnosis of sCJD in the early stage of disease. And sCJD-associated neuropathologic brainstem abnormalities on DWI are considered uncommon. Here, we provided a sequential neuroimaging of a late-onset sCJD with medulla oblongata motor nuclei lesion.
Case presentation: We report the case of a 77-year-old woman who presented a typical late-onset sCJD clinical manifestation including rapidly progressive dementia, ataxia, and myoclonus, except vision loss. 14-3-3 protein of CSF was found to be positive, blood gene test detected that the polymorphism at codon 129 was M/M subtypes, genotyping the human prion protein gene (PRNP) did not reve.. View More»
DOI:
10.4172/2165-8048.1000218