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Internal Medicine: Open Access

Internal Medicine: Open Access
Open Access

ISSN: 2165-8048

Jie Liu

Jie Liu

China

Publications
  • Research Article
    Independent Association of 9p21 Locus and Sub clinical Atherosclerosis
    Author(s): Yanan Wei, Lingxia Chen, Jie Liu and Yide MiaoYanan Wei, Lingxia Chen, Jie Liu and Yide Miao

    Methods: 361 Han Chinese elderly in Beijing were included. These subjects underwent the following procedures: (1) Personal medical history and physical examination; (2) Routine blood chemistry and urine analysis; (3) Left ventricular mass index was obtained by echocardiography, and ultrasound evaluation of carotid intima-media thickness. We tested the genotypes of six single nucleotide polymorphisms on chromosome 9p21 (rs2383206, rs10965234, rs10965235, rs10757277, rs10811656 and rs1333047). Results: For the SNP rs2383206, Genotypes with allele A (AA/AG) was significantly associated with higher CCA IMT (p=0.003). For the SNP rs1075277, Genotypes with allele A (AA/AG) was significantly associated with higher CCA IMT as well (p=0.021). This phenomenon was not observed in ICA IMT and LVH. After adjustment for age, sex, BMI, SBP, DBP, TC, F.. Read More»
    DOI: 10.4172/2165-8048.1000118

    Abstract PDF

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