Biochemistry & Pharmacology: Open Access
Open Access

Jiapu Zhang

Publications

• Research Article
  The Hybrid Idea of (Energy Minimization) Optimization Methods Applied to Study PrionProtein Structures Focusing on the beta2-alpha2 Loop
  Author(s): Jiapu ZhangJiapu Zhang
  
  In molecular mechanics, current generation potential energy functions provide a reasonably good compromise between accuracy and effectiveness. This paper firstly reviewed several most commonly used classical potential energy functions and their optimization methods used for energy minimization. To minimize a potential energy function, about 95% efforts are spent on the Lennard-Jones potential of van der Waals interactions; we also give a detailed review on some effective computational optimization methods in the Cambridge Cluster Database to solve the problem of Lennard- Jones clusters. From the reviews, we found the hybrid idea of optimization methods is effective, necessary and efficient for solving the potential energy minimization problem and the Lennard-Jones clusters problem. An application to prion protein structures is then done by the hybrid idea... View More»
  DOI: 10.4172/2167-0501.1000175

  Abstract PDF

Relevant Topics