Internal Medicine: Open Access
Open Access

Jiande D Z Chen

Publications

• Research Article
  Peripheral Effects of Rimonabant on Upper Gastrointestinal Motility
  Author(s): Yan Sun, Geng-Qing Song and Jiande D Z ChenYan Sun, Geng-Qing Song and Jiande D Z Chen
  
  Background: Rimonabant (SR 141716A) is an antagonist-inverse agonist of cannabinoid receptor 1 (CB1), which was developed for the obesity treatment. The aim of this study was to investigate effects of rimonabant on gastric emptying, gastric tone, accommodation and compliance, antral contractions and small intestinal contractions in dogs. Materials and Methods: Six dogs were equipped with a duodenal cannula for the measurements of gastricemptying, small bowel contractions and small bowel slow waves. Another six dogs were equipped with a gastric cannula for the measurements of gastric tone, accommodation and compliance, antral contractions and gastric slow waves. Each of the measurements was obtained in one control and two rimonabant sessions (different doses). Results: 1) Rimonabant accelerated ga.. Read More»
  DOI: 10.4172/2165-8048.1000116

  Abstract PDF

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