Internal Medicine: Open Access

Internal Medicine: Open Access
Open Access

ISSN: 2165-8048

+44-74-82-87-62-02

Jiande D Z Chen

Jiande D Z Chen

Galveston, TX 77555
Tanzania

Publications
  • Research Article
    Peripheral Effects of Rimonabant on Upper Gastrointestinal Motility
    Author(s): Yan Sun, Geng-Qing Song and Jiande D Z ChenYan Sun, Geng-Qing Song and Jiande D Z Chen

    Background: Rimonabant (SR 141716A) is an antagonist-inverse agonist of cannabinoid receptor 1 (CB1), which was developed for the obesity treatment. The aim of this study was to investigate effects of rimonabant on gastric emptying, gastric tone, accommodation and compliance, antral contractions and small intestinal contractions in dogs. Materials and Methods: Six dogs were equipped with a duodenal cannula for the measurements of gastricemptying, small bowel contractions and small bowel slow waves. Another six dogs were equipped with a gastric cannula for the measurements of gastric tone, accommodation and compliance, antral contractions and gastric slow waves. Each of the measurements was obtained in one control and two rimonabant sessions (different doses). Results: 1) Rimonabant accelerated ga.. Read More»
    DOI: 10.4172/2165-8048.1000116

    Abstract PDF

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