Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Hong-Na Wang
Indiana
Short Communication
The Influence of GSTA1 Polymorphism to the Response to Intravenous Cyclophosphamide Therapy in the Lupus Nephritis Patients
Author(s): Hong-Na Wang, Xiao-Ye Zhu, Ying Zhu, Miao Zhao, Yuan-Cheng Chen, Jun Xue, Chuan-Ming Hao, Yong Gu and Shan-Yan LinHong-Na Wang, Xiao-Ye Zhu, Ying Zhu, Miao Zhao, Yuan-Cheng Chen, Jun Xue, Chuan-Ming Hao, Yong Gu and Shan-Yan Lin
Variations of clinical response of cyclophosphamide (CTX) treatment in lupus nephritis (LN) could still be recognized. LN patients with a GSTA1mutation (CT heterozygous) had a risk of none-response (P=0.005). Pharmacokinetics data indicated that patients with a GSTA1 heterozygous variant had a lower exposure to 4-OHCTX compared to wild-type patients (P=0.023). And clinical efficacy was significantly related to higher exposure to 4- OH-CTX (P=0.038). In conclusion, LN patients with GSTA1 heterozygousgenotypes had poor CTX treatment response due to less exposure to activated 4-OH-CTX... View More»
DOI:
10.35248/2684-1630.16.1.115