Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Ghanizadah MA
West Indies
Research Article
Effect of Transdermal Nitroglycerin on Insulin Resistance in Healthy Young Men
Author(s): Babaei A, Mohammadi SM, Sultani MH and Ghanizadah MABabaei A, Mohammadi SM, Sultani MH and Ghanizadah MA
Objective: There are evidences indicating transdermal nitroglycerin changes the sensitivity of peripheral tissues to the hypoglycemic effect of insulin. In this study we determined effect of continuous application of transdermal nitroglycerin patches in healthy volunteers on development of tolerance to the hypotensive effect of nitroglycerin and hypoglycemic effect of insulin.
Materials and methods: The effect of transdermal application of nitroglycerin, as NO donor was studied during 24 hours on blood insulin and glucose level and on blood pressure in healthy, young volunteers. Patches of 0.2 mg/ hour nitroglycerine were administered to young healthy volunteers along 24 hours and Venous blood samples were taken early before and 24 hours after the nitroglycerin. Serum was separated and free zed (-80°C) for insulin and glucose determination. Blood pressure also was determ.. View More»
DOI:
10.4172/2165-8048.1000190