Internal Medicine: Open Access
Open Access

Frank Comhaire

Publications

• Review Article
  Chronic Fatigue Syndrome (CFS) or “Systemic Immune Disorder” (SID)?
  Author(s): Frank Comhaire and Gabriël DevriendtFrank Comhaire and Gabriël Devriendt
  
  It is the opinion of the authors that the disease called chronic fatigue syndrome (CFS), or fibromyalgia, or myalgic encephalomyelitis, is primarily due to a disorder of the immune system and should rather be called “systemic immune disorder”. This disorder probably results from external factors such as inadequate stress adaptation, or a (retro)-viral infection deregulating the function of the memory T-lymphocytes in persons who are predisposed because of genetic or epigenetic alterations. Chronic inflammation with overproduction of cytokines, reactive oxygen and nitrogen species causes mitochondrial dysfunction with metabolic disturbance resulting in muscular and cerebral signs and symptoms. The reference treatment consisting of cognitive behavioural therapy (CBT) and graded exercising (GET) considers CFS to be a somatoform disease, but was proven ineffective. Caus.. View More»
  DOI: 10.4172/2165-8048.1000225

  Abstract PDF

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