Journal of Medical Diagnostic Methods
Open Access
ISSN: 2168-9784
+44 1300 500008
ISSN: 2168-9784
+44 1300 500008
Felix-Martin Werner
Höhere Berufsfachschule für Altenpflege und Ergotherapie der Euro Akademie Pößneck,
Pößneck
Germany
Review Article
Assessments in Primary Parkinson Syndrome for comparison between Monodopaminergic and Multi-target Anti-parkinsonian Pharmacotherapies
Author(s): Felix-Martin Werner and Rafael CoveñasFelix-Martin Werner and Rafael Coveñas
In this review, the altered functions of neurotransmitters and neuropeptides in the extrapyramidal system in primary Parkinson syndrome are pointed out. In this syndrome, an altered neurotransmitter balance in the nuclei of the extrapyramidal system with hypoactivity of the dopaminergic and GABAergic neurotransmitter systems and hypoactivity of the muscarinic cholinergic and glutamatergic neurotransmitter systems occurs. Serotonin counteracts dopamine deficiency in the putamen via 5-HT2A receptors. Neuropeptides have a modulating function and influence the mentioned neurotransmitter systems. Neurotensin antagonists, at NTS1 receptors, and antagonists, at the mu opioid receptor, could have a therapeutic function in the anti-Parkinsonian pharmacotherapy. A scheme including the possible neural combinations in the neuronal system and considering the mentioned alterations of the.. View More»
DOI:
10.4172/2168-9784.1000241