Lupus: Open Access
Open Access

Donald Massenburg

Publications

• Research Article
  Using the SLE-key® Rule-Out Test in Clinical Practice
  Author(s): Donald Massenburg, Justine Oldenberg, Amanda Sell, Tristan Krause and Alvin F. WellsDonald Massenburg, Justine Oldenberg, Amanda Sell, Tristan Krause and Alvin F. Wells
  
  Objectives: The patient referred to a rheumatology clinic for workup of suspected Systemic Lupus Erythematosus (SLE) often presents a difficult diagnostic problem; until recently, there have been no objective tests validated to rule in or rule out SLE and the diagnosis is based on a list of criteria that may be open to interpretation. Methods: To approach this problem, a serologic rule out test for SLE was developed based on antigen microarray profiling of multiplex antibody reactivities. This SLE-key® test was developed by ImmunArray and, using stored serum samples from recognized academic centers, was validated to rule out SLE with 94% sensitivity, 75% specificity and a negative predictive value (NPV) of 93%. In clinical practice, however, patients are referred one at a time from peripheral clinical units, often with incomplete documentat.. View More»
  DOI: 10.35248/2684-1630.17.2.126

  Abstract PDF

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