Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-77-2385-9429
ISSN: 2157-7048
+44-77-2385-9429
Dipak K Sarker
Interfacial Nanotechnology Group, School of Pharmaceutical and Biomolecular Sciences,
Lewes Road, Brighton, BN2 4GJ
United Kingdom
Research Article
SLNs can Serve as the New Brachytherapy Seed: Determining Influence of
Surfactants on Particle Size of Solid Lipid Microparticles and Development
of Hydrophobised Copper Nanoparticles for Potential Insertion
Author(s): Kshitij R Mistry and Dipak K Sarker
Kshitij R Mistry and Dipak K Sarker
Solid lipid nanoparticles (SLNs) or technically speaking, larger solid lipid microparticles are emerging as a noninvasive technique for drug-delivery, carrying forward advantages of conventional nanostructured systems and eliminating their drawbacks. This study involves the analysis of solid lipid microparticles generated via hot high-shear homogenization technique with tristearin as the main lipid component and phosphate buffer (pH 7.00) as the aqueous phase (phase volume 0.2). This study aims to identify the effects of the chosen lipid, and four non-ionic surfactants (TweenŽ20, TweenŽ80, Lutrol F68 and Lutrol F127) on particle size of solid lipid microparticles. Samples generating particle sizes of less than 200 nm were further analysed via SEM to determine morphological characteristics of SLNs. SLN composition is crucial as it determines various chemical and physical properties of the.. View More»
DOI:
10.4172/2157-7048.1000302