Journal of Women's Health Care
Open Access

Bostwick GD

Publications

• Research Article
  Utility of Next-generation sequencing in Managing Bacterial Vaginosis: Examples from Clinical Practice
  Author(s): Bostwick GD, Hunt CA, Parker LR, Daniel Mcdyer, Woody J and Budd WBostwick GD, Hunt CA, Parker LR, Daniel Mcdyer, Woody J and Budd W
  
  There is an unacceptably high recurrence rate for bacterial vaginosis and vaginitis owing to multiple causes, including misdiagnosis and empirical under-treatment and over-treatment. A diagnostic test that provided complete knowledge of the vaginal microbiome in patients with bacterial vaginosis (BV) would fill an important void. In initial evaluations of Next-generation Sequencing (NGS), this new test offers great promise.As a clinical diagnostic for primary or recurrent bacterial vaginosis, NGS by simple vaginal swab offers heightened sensitivity and specificity compared to culture or limited three-organism genetic tests. NGS holds valuable potential in multiple BV quandary situations, including: (a) Recurrent BV in a patient that failed initial therapy, (b) Symptoms of BV in a patient with false-positive Amsel criteria, (c) Gardnerellavaginalis-negative BV with mixed infection. Mul.. View More»
  DOI: 10.4172/2167-0420.1000322

  Abstract PDF

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