Lupus: Open Access
Open Access
ISSN: 2684-1630
+44 1300 500008
ISSN: 2684-1630
+44 1300 500008
Audrey A Margery-Muir
School of Biomedical Sciences,
GPO box U1987 Bentley Western
Australia
Research Article
Anti-C1Q Antibodies Concentrations by Elisa in Systemic Lupus Erythematosus
Author(s): Audrey A Margery-Muir, John D Wetherall, David M Groth and Christine BundellAudrey A Margery-Muir, John D Wetherall, David M Groth and Christine Bundell
Systemic lupus erythematosus (SLE) is an inflammatory disorder in which autoantibodies contribute to impaired apoptosis and clearance of cell debris. Anti dsDNA and anti C1q antibodies have been implicated, as well as complement protein C1q itself. IgG autoantibodies reacting with the collagen-like region of C1q protein (αC1q ab) were quantitated in serum of 56 patients diagnosed with SLE and undergoing treatment for variable periods, together with 33 age/sex-matched controls. Analysis of the results showed optimal sensitivity and specificity of 57% and 91% respectively at a cut-off concentration for positivity of 20 U/ml. The assay is a potentially useful confirmatory test for SLE, but is not suitable as a screening test for SLE with the probability of a positive test and SLE in an individual within a random population of only ≤ 1%. αC1q ab concentrations were detectab.. View More»
DOI:
10.35248/2684-1630.17.2.124