Journal of Medical & Surgical Pathology
Open Access
ISSN: 2472-4971
+44 1223 790975
ISSN: 2472-4971
+44 1223 790975
Angelica M. Silva-Figueroa
Hospital Barros Luco-Trudeau, Santiago
Chile
Mini Review
Parathyroid Carcinoma has a PD-L1 Expression, and Share with Atypical Neoplasms an Abundant Intratumoral Macrophagic Infiltration - A Short Commentary
Author(s): Angelica M. Silva-Figueroa and Nancy D. PerrierAngelica M. Silva-Figueroa and Nancy D. Perrier
Background: In the era of immunotherapy as a therapeutic option for solid tumors, the immuno-tumor characterization of parathyroid neoplasms is timely and necessary. Since conventional therapeutic options are limited for controlling the progression of parathyroid carcinoma, new modalities of treatment are desperately needed. Four distinct tumor microenvironments have been proposed based on the existence of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1); type I (TILs+/PD-L1+), type II (TILs-/PD-L-), type III (TILs-/PD-L1+), and type IV (TILs+/PD-L1-). These immunogenic subtypes may predict responses to these therapies.
Aim: The aim of this study was characterized programmed death-ligand 1 (PD-L1) expression and tumoralinfiltrating lymphocytes (TILs) in parathyroid carcinoma (PC) and atypical parathyroid neoplasms (AN.. View More»
DOI:
10.4172/2472-4971.1000166