Journal of Pharmacological Reports
Open Access
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Alcantara LM
Brazil
Research Article
Anti-Leishmanial Activity of a Library of Synthetic 4-Substituted 2-(1H-Pyrrolo [3, 2-c] Pyridin-2-Yl) Propan-2-Ols
Author(s): Balfour MN, Alcantara LM, Ferreira TCS, Menezes CMS, Moraes CB, Freitas-Junior LH and Stefani HABalfour MN, Alcantara LM, Ferreira TCS, Menezes CMS, Moraes CB, Freitas-Junior LH and Stefani HA
Leishmaniasis is a devastating parasitic disease of medical and veterinary importance that is endemic across the tropics. It can be either disfiguring or lethal in its most severe forms and it lacks appropriate treatment. Several species of the protozoan parasite Leishmania can cause Leishmaniasis in human, which further complicates the development of new therapeutics because the different species are genotypically and phenotypically diverse. We have previously reported the anti-protozoal activity of 4-substituted 2-(1H-pyrrolo [3, 2-c] pyridin-2-yl) propan-2-ols against the related protozoan, Trypanosoma cruzi. Herein we report the biological activity of some of these compounds against intracellular amastigotes of three of the most clinically relevant Leishmania species: L. amazonensis, L. braziliensis and L. infantum. Four of the tested compound showed activity against the three Lei.. View More»